“It’s like a war. You don’t know whether you’re going to win the war. You don’t know if you’re going to survive the war. You don’t know if the project is going to survive the war.” The war? Cancer, still one of the leading causes of death despite 40 years passing since the National Cancer Act of 1971 catapulted Richard Nixon’s famous “War on Cancer.” The speaker of the above quote? A scientist at Genentech, a San Francisco-based biotechnology and pharmaceutical company, describing efforts to pursue a then-promising miracle treatment for breast cancer facing numerous obstacles, not the least of which was the patients’ rapid illness. If it sounds like a made-for-Hollywood story, it is. But I Want So Much To Live is no ordinary documentary. It was commissioned as an in-house documentary by Genentech, a rarity in the staid, secretive scientific corporate world. The production values and storytelling offer a tremendous template for Hollywood filmmakers, as science and biomedical content become even more pervasive in film. Finally, the inspirational story behind Herceptin, one of the most successful cancer treatments of all time, offers a testament and rare insight to the dedication and emotion that makes science work. Full story and review under the “continue reading” cut. Continue reading From The Lab: Pharmaceutical Documentary a Blueprint for Hollywood Science Storytelling→
…a nanoscientist’s quest to mimic Nature’s molecular blueprints
Have you ever found yourself entranced by the exquisite beauty and complexity of living things? Like the intricacies of a budding flower, or the mesmerizing patterns on a butterfly’s wing? Have you ever wondered: “what are living things made of?” Are these materials just as beautiful if we were to zoom way way in and look at the actual molecular building blocks that make up life? Take a look at the interactive link The Scale of Things to see just how small the building blocks of life really are! Well the answer is “OMG – totally!” All living things share a ubiquitous set of molecular building materials we call proteins, and they are absolutely stunning! They are not only smashingly beautiful to look at, they are capable of performing a mind-numbing myriad of very intricate and complex functions that are essential to life. In a very special guest post, leading nanoscience Professor Ron Zuckermann of the renowned Lawrence Berkeley National Laboratory recounts his life’s mission as a chemist to try and build artificial microscale sheets made up of nature’s very own building blocks—proteins. Everything you wanted to know about what nanotechnology is, exactly, why engineering proteins is the science of the future, and what we plan to use these discoveries for, under the “continue reading” cut. Continue reading Guest Article: Beauty and the Building Blocks…→
About a week and a half ago, scientists achieved a remarkable evolutionary stepping stone in the technological holy grail of eventually engineering synthetic life. Nicknamed ‘Synthia’ by her experimental progenitors, the latest discovery is a viable, self-propagating yeast cell hosting a bacterial Mycoplasma mycoides genome (consisting of non-biological DNA) purely composed in the laboratory. In eerily apt timing, Splice, a new science fiction thriller premiering this week, explores the scientific ramifications and bioethical morass encompassing the creation of a human-animal hybrid by a rogue superstar genetics couple. Under the “continue reading” cut, ScriptPhD.com’s review of Splice, discussion of the expanding frontiers of genetic engineering, and a special video interview with the director/writer, producer and stars of the film.
Society’s unequivocal fascination with science and scientists, reflected by a growing presence as staples of film, television, and popular culture, has only been magnified by the enigmatic (and seemingly impenetrable) aura in which they are enveloped. Their studies decidedly abstruse, their coded language unintelligible, their habits quirky and eccentric, the world of the scientist has been an audiovisual shroud of mystery—until now. In perhaps the most authentic, unfiltered, extemporaneous portrayal of scientists in their environment ever recorded, new documentary Naturally Obsessed: The Making of a Scientist welcomes the lay audience into the laboratory as silent observers. No reservations, no restrictions, no preconceptions. The result is an emotionally stunning masterpiece that connects us to scientists as people, reaches out across professional divides, and places PhD students, the backbone of the modern scientific laboratory, under the microscope for the first time. ScriptPhD.com recently screened the movie with a group of UCLA PhD biology students. Under the “continue reading” cut is our review, along with an honest roundtable discussion that included reaction to the movie, its parallel to their lives, and the training of modern scientists. Continue reading ScriptPhD Roundtable: Naturally Obsessed—The Making of a Scientist→
In 2006, The Discovery Channel, in partnership with the BBC, premiered the 11-part Planet Earth, the most expensive natural history mini-series ever filmed, and the first in high definition. It gave viewers a sweeping, intimate overview of the Earth’s diverse natural habitats. Yet long before Planet Earth premiered, plans were already underway for its follow-up opus, LIFE, which would focus on the animals, insects, and creatures that call those habitats home. The result, four years in the making, is historic television—never-before-recorded mating rituals, survival scenes, and brutal savagery. For the naturalist and the nature-lover, LIFE will, quite simply, change your view of life. After the “continue reading” cut, we preview the first few episodes and offer a rare candid interview with executive producer Mike Gunton. We are proud to make LIFE on Discovery Channel an official ScriptPhD.com Editor’s Selection. Continue reading Discovering LIFE on Planet Earth—Editor’s Selection→
You spot someone across a crowded room. There is eye contact. Your heart beats a little faster, palms are sweaty, you’re light-headed, and your suddenly-squeamish stomach has dropped to your knees. You’re either suffering from an onset of food poisoning or you’re in love. But what does that mean, scientifically, to fall in love, to be in love, to stay in love? In our special Valentine’s Day post, Editor Jovana Grbić expounds on the neuronal and biophysical markers of love, how psychologists and mathematicians have harnessed (and sometimes manipulated) this information to foster 21st Century digital-style romance, and concludes with a personal reflection on what love really means in the face of all of this science. You might just be surprised. So, Cupid, draw back your sword… and click “continue reading” for more! Continue reading Love is a Many-Splendored Algorithm→