One of my favorite movies as a kid, and now, as a professional scientist, is Andromeda Strain. The heroes are mostly older, professorial types who work feverishly to understand an alien organism and save the planet. After being asked to review ReAction! Chemistry in the Movies for ScriptPhD.com, I was so curious to consume (with relish) the book’s guesswork about the chemistry found in Andromeda Strain. After returning to the beginning of the book and giving it a read, I was thrilled to find that ReAction! is a detailed, thoughtful exploration of the representation of chemistry in film. The book addresses, first and foremost, the fact that chemistry can play a lead role in film. The authors also discuss the dichotomy between the dark and bright sides of chemistry (and science) as illustrated by films in which chemistry or chemists play a central role. Also included are several playful explorations of the real science behind some famous examples of fictional chemistry in film. After the break is a full review of the book along with an in-depth interview with authors Mark Griep and Majorie Mikasen on the process of working together as chemist and artist, portrayal of chemists in film and how film can change public perception in science.